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AffiliationDepartment of ImmunologyGeneticsand PathologyRudbeck LaboratorySciLifeLabUppsala UniversityUppsalaSweden.
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Several infrequent genetic polymorphisms in the SERPINA1 gene are known to substantially reduce concentration of alpha1-antitrypsinAATin the bloodSince low AAT serum levels fail to protect pulmonary tissue from enzymatic degradationthese polymorphisms also increase the risk for early onset chronic obstructive pulmonary diseaseCOPDThe role of more common SERPINA1 single nucleotide polymorphismsSNPsin respiratory health remains poorly understood.
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