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Estrogen administration leads to increased thyroid-binding globulinTBGlevelsWomen with normal thyroid function can compensate for the increased TBG by making more thyroid hormonethus maintaining free T4 and T3 serum concentrations in the normal rangeWomen dependent on thyroid hormone replacement therapy who are also receiving estrogens may require increased doses of their thyroid replacement therapyThese women should have their thyroid function monitored in order to maintain their free thyroid hormone levels in an acceptable range.

Epidemiological evidence from a large meta-analysis suggests a slightly increased risk in women taking estrogen-only or combined estrogen-progestogen HRTwhich becomes apparent within 5 years of use and diminishes over time after stopping.

Your doctor should check your progress on a regular basis to determine whether you should continue this treatmentSelf-examine your breasts for lumps on a monthly basisand have regular mammograms.

Unless there is a previous diagnosis of endometriosisit is not recommended to add a progestogen in hysterectomised women.

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