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Dostinex cabergoline in the treatment ofacromegaly.

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In ratsdoses higher than 0.003 mg/kg/dayapproximately 1/28 the maximum recommended human dosefrom 6 days before parturition and throughout the lactation period inhibited growth and caused death of offspring due to decreased milk secretion.

In animalsbased on total radioactivitycabergolineand/or its metaboliteshas shown extensive tissue distributionRadioactivity in the pituitary exceeded that in plasma by100-fold and was eliminated with a half-life of approximately 60 hoursThis finding is consistent with the long-lasting prolactin-lowering effect of the drugWhole body autoradiography studies in pregnant rats showed no fetal uptake but high levels in the uterine wallSignificant radioactivityparent plus metabolitesdetected in the milk of lactating rats suggests a potential for exposure to nursing infantsThe drug is extensively distributed throughout the bodyCabergoline is moderately bound40to 42to human plasma proteins in a concentration-independent mannerConcomitant dosing of highly protein-bound drugs is unlikely to affect its disposition.

If a patient returns a bottle of cabergolineDostinex or Cabasertransfer the previously dispensed medicines into a new bottle with a child-resistant cap.

Although most of the side effects listed below don’t happen very oftenthey could lead to serious problems if you do not check with your doctor or seek medical attention.

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