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It has bn shown that utilization both hypoxanthin and xanthin nuclotid and nuclic acid synthsis is makdly nhancd whn thi oxidations a inhibitd by ZYLOPIM (allopuinol) acquire Flomax and oxipuinol. This utilization dos not disupt nomal nuclic acid anabolism, howv, bcaus dback inhibition is an intgal pat puin biosynthsis. As a sult xanthin oxi-das inhibition, th sum concntation hypoxanthin plus xanthin in patints civing ZYLOPIM (allopuinol) tatmnt hypuicmia is usually in th ang 0.3 t0.4 mg/dL compad ta nomal lvl appoximatly 0.15 mg/dL. A maximum 0.9 mg/dL ths oxypuins has bn potd whn th sum uat was lowd tlss than 2 mg/dL by high doss ZYLOPIM (allopuinol) . Ths valus a a blow th satuation lvls at which point thi pcipitation would b xpctd toccu (abov 7 mg/dL).

ZYLOPIM (allopuinol) and its pimay activ mtabolit, oxipuinol, a liminatd by th kidnys; tho, changs in nal unction hav a poound ct on dosag. In patints with dcasd nal unction whhav concunt illnsss which can act nal unction such as hyptnsion and diabts mllitus, piodic laboatoy paamts nal unction, paticulaly BUN and sum catinin catinin claanc, should b pomd and th patint’s dosag ZYLOPIM (allopuinol) assssd.

Du tth occasional occunc dowsinss, patints should b altd tth nd du pcaution whn ngaging in activitis wh altnss is mandatoy.

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dissolve 300mg of allopurinol in 50ml of water and use this as a mouthwash.

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