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The anti-nausea drug Zofran is approved for the prevention of nausea and vomiting caused by cancer chemotherapyradiation and surgeryDoctors also prescribe the medication to treat morning sicknessthough studies offer conflicting results about its potential for causing birth defects.

The following adverse reactions have been identified during post-approval use of ondansetronBecause these reactions are reported voluntarily from a population of uncertain sizeit is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

FlushingRare cases of hypersensitivity reactionssometimes severee.ganaphylactic reactionsangioedemabronchospasmshortness of breathhypotensionlaryngeal edemastridorhave also been reportedLaryngospasmshockand cardiopulmonary arrest have occurred during allergic reactions in patients receiving injectable ondansetron.

It is not known whether ondansetron passes into breast milk or if it could harm a nursing babyDo not use this medication without telling your doctor if you are breast-feeding a baby.

ElectrocardiogramECGchanges including QT interval prolongation have been seen in patients receiving ondansetronIn additionpostmarketing cases of Torsade de Pointes have been reported in patients using ZOFRANAvoid ZOFRAN in patients with congenital long QT syndromeECG monitoring is recommended in patients with electrolyte abnormalitiese.ghypokalemia or hypomagnesemiacongestive heart failurebradyarrhythmiasor patients taking other medicinal products that lead to QT prolongationsee CLINICAL PHARMACOLOGY

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