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The use of estrogen plus progestin has been reported to result in an increase in abnormal mammograms requiring further evaluationAll women should receive yearly breast examinations by a healthcare provider and perform monthly breast self-examinationsIn additionmammography examinations should be scheduled based on patient agerisk factorsand prior mammogram results.
In a small number of case reportssubstantial increases in blood pressure have been attributed to idiosyncratic reactions to estrogensIn a largerandomizedplacebo-controlled clinical triala generalized effect of estrogens on blood pressure was not seenBlood pressure should be monitored at regular intervals with estrogen use.
No pharmacokinetic studies were conducted in special populationsincluding patients with renal or hepatic impairment.
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it is believed that estrace works in cases of endometriosis by replenishing estrogen levels decreased by other hormonal medications.