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, furosemide, bumetanide, torsemide may be particularly useful in patients with renal impairment as an alternative to thiazide diuretics or heart failure for management of fluid retention .

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Pharmacodynamics Diuretic actionLoop diuretics inhibit sodium and chloride reabsorption in the proximal part of the ascending loop of Henlepromoting the excretion of sodiumwaterchlorideand potassiumAntihypertensive actionThis drug effect may be the result of renal and peripheral vasodilatation and a temporary increase in glomerular filtration rate and a decrease in peripheral vascular resistance.

LasixFurosemideis one of the most commonly prescribed medications for the treatment of hypertensionwhich is accompanied by massive swellingThe therapeutic effectiveness of this medication has been confirmed by data reported in clinical trialsIn most casesLasix is used as one of the primary components involved in the complex therapy for essential hypertension.

Adverse reactions CNSvertigoheadachedizzinessparesthesiarestlessnessfeverCVvolume depletion and dehydrationorthostatic hypotensionthrombophlebitis with I.VadministrationEENTtransient deafness with too-rapid I.Vinjectionblurred visionGIabdominal discomfort and paindiarrheaanorexianauseavomitingconstipationPANCREATITISGUnocturiaazotemiapolyuriafrequent urinationrenal failureoliguriaHematologicagranulocytosisleukopeniathrombocytopeniaanemiaaplastic anemiaMetabolichypokalemiahypochloremic alkalosisasymptomatic hyperuricemiafluid and electrolyte imbalancesincluding dilutional hyponatremiahypocalcemiahypomagnesemiahyperglycemiaimpaired glucose toleranceMusculoskeletalmuscle spasmweaknessSkindermatitispurpuratransient pain at I.Minjection site.

Lasix overdose results in rapid dehydrationThe BCC decreasesthe volume of circulating bloodand cardiac arrhythmias and/or blockades developBlood pressure also sharply dropsacute renal failure occursand consciousness is disturbed.

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