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The fev 1 auc 0-4h for combivent respimat 20 100 mcg , was superior to that of atrovent bromide ls mean ml 95 ci of the treatment difference was 47 ml 28, 66 andthe mean fev 1 auc 4-6h for atrovent 20 100 mcg was non-inferior to that ofipratropium bromide ls mean ml 95 ci of the treatment differencewas -17 -39, 5 .

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Studies in laboratory animalsminipigsrodentsand dogshave demonstrated the occurrence of cardiac arrhythmias and sudden deathwith histologic evidence of myocardial necrosiswhen beta-agonists and methylxanthines were administered concurrentlyThe significance of these findings when applied to humans is unknown.

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Applies to albuterolipratropiuminhalation aerosol liquidinhalation aerosol powderinhalation solutioninhalation spray.

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