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The fev 1 auc 0-4h for combivent respimat 20 100 mcg , was superior to that of atrovent bromide ls mean ml 95 ci of the treatment difference was 47 ml 28, 66 andthe mean fev 1 auc 4-6h for atrovent 20 100 mcg was non-inferior to that ofipratropium bromide ls mean ml 95 ci of the treatment differencewas -17 -39, 5 .

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Studies in laboratory animalsminipigsrodentsand dogshave demonstrated the occurrence of cardiac arrhythmias and sudden deathwith histologic evidence of myocardial necrosiswhen beta-agonists and methylxanthines were administered concurrentlyThe significance of these findings when applied to humans is unknown.

Additional adverse reactionsreported in less than two percent of the patients in the COMBIVENT Inhalation Aerosol treatment group include edemafatiguehypertensiondizzinessnervousnessparesthesiatremordysphoniainsomniadiarrheadry mouthdyspepsiavomitingarrhythmiapalpitationtachycardiaarthralgiaanginaincreased sputumtaste perversionand urinary tract infection/dysuria.

Applies to albuterolipratropiuminhalation aerosol liquidinhalation aerosol powderinhalation solutioninhalation spray.

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