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Adjust colchicine dosage see dosage under dosage and administration 164.

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If you are taking colchicine to prevent gout attackscall your doctor right away if common side effects of synthroid you experience a gout attack during your treatmentYour doctor may tell you to take an extra dose of colchicinefollowed by a smaller dose one hour laterIf you take extra doses of colchicine to treat a gout attackyou should not take your next scheduled dose of colchicine until at least 12 hours have passed since you took the extra doses.

General information about the safe and effective use of colchicine capsules.

If you are taking colchicine to treat FMFyour doctor may start you on a low dose and gradually increase your doseYour doctor may decrease your dose if you experience side effects.

There are no adequate and well-controlled studies with colchicine capsules in pregnant womenColchicine crosses the human placentaDevelopmental studies in animals were not conducted with colchicine capsuleshowever published animal reproduction and development studies with colchicine demonstrated embryofetal toxicityteratogenicityand altered postnatal development at exposures within or above the clinical therapeutic rangeColchicine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Physicians should ensure that patients are suitable candidates for treatment with colchicine capsules and remain alert for signs and symptoms of toxic reactions associated with increased colchicine exposure due to drug interactionsSigns and symptoms of colchicine toxicity should be evaluated promptly andif toxicity is suspectedcolchicine capsules should be discontinued immediately.

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