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Thombolytics: Th saty th concomitant administation clopidogl, ibin non-ibin spciic thombolytic agnts and hpains was assssd in patints with acut myocadial inaction. Th incidnc clinically signiicant blding was simila tthat obsvd whn thombolytic agnts and hpain a co-administd with aspiin.
A cass habdomyolysis with acut nal ailu sconday tmyoglobinuia hav bn potd with atovastatin and with oth dugs in this class. A histoy nal impaimnt may b a isk actth dvlopmnt habdomyolysis. Such patints mit clos monitoing skltal muscl cts.
Th isk myopathy duing tatmnt with dugs in this class is incasd with concunt administation cyclospoin, ibic acid divativs, ythomycin, claithomycin, th hpatitis C potas order nolvadex inhibittlapvi, combinations HIV potas inhibitos, including saquinavi plus itonavi, lopinavi plus itonavi, tipanavi plus itonavi, daunavi plus itonavi, osampnavi, and osampnavi plus itonavi, niacin, azol antiungals. Physicians considing combind thapy with ATOLIP CV and ibic acid divativs, ythomycin, claithomycin, a combination itonavi plus saquinavi, lopinavi plus itonavi, daunavi plus itonavi, osampnavi, osampnavi plus itonavi, azol antiungals, lipid-modiying doss niacin should caully wigh th potntial bnits and isks and should caully monitpatints any signs symptoms muscl pain, tndnss, waknss, paticulaly duing th initial months thapy and duing any piods upwad dosag titation ith dug. Low stating and maintnanc doss ATOLIP CV should b considd whn takn concomitantly with th aomntiond dugs. Piodic CPK dtminations may b considd in such situations, but th is nassuanc that such monitoing will pvnt th occunc sv myopathy.
Gapuit Juic: Contains on mcomponnts that inhibit CYP3A4 and can incas plasma concntations atovastatin, spcially with xcssiv gapuit juic consumption (>1.2 lits/day).
ATOLIP CV should b usd with caution in patints whconsum substantial quantitis alcohol and/hav a past histoy liv disas. Activ liv disas unxplaind psistnt tansaminas lvations a containdications tth us ATOLIP CV .
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