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Wellbutrin xl has been demonstrated to have similar bioavailability both to the immediate-release formulation of bupropion and to the sustained-release formulation of bupropion see clinical pharmacology .

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You may have a higher risk of seizures if you use certain other medicines while taking bupropion.

Co-administration may cause serotonin syndrome Do not use concomitantly or initiate bupropion within 14 days of stopping an MAOI Converselyat least 14 days should be allowed after stopping bupropion before starting an MAOI antidepressant Starting bupropion in a patient who is being treated with linezolid or IV methylene blue is contraindicated because of an increased potential of serotonin syndrome If linezolid or IV methylene blue must be administereddiscontinue bupropion immediately and monitor for CNS toxicitymay resume 24 hours after last linezolid or methylene blue dose or after 2 weeks of monitoringwhichever comes first.

Report any new or worsening symptoms to your doctorsuch asmood or behavior changesanxietydepressionpanic attackstrouble sleepingor if you feel impulsiveirritableagitatedhostileaggressiverestlesshyperactivementally or physicallyor have thoughts about suicide or hurting yourself.

Coadministration may cause serotonin syndrome Do not use concomitantly or initiate bupropion acquire atarax within 14 days of stopping an MAOI Converselyat least 14 days should be allowed after stopping bupropion before starting an MAOI antidepressant Starting bupropion in a patient who is being treated with linezolid or IV methylene blue is contraindicated because of an increased risk of serotonin syndrome If linezolid or IV methylene blue must be administereddiscontinue bupropion immediately and monitor for CNS toxicitymay resume 24 hr after last linezolid or methylene blue dose or after 2 weeks of monitoringwhichever comes first.

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