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Tak this mdication by mouth with without ood as dictd by you docto, usually onc daily. Dosag is basd on you mdical condition, spons ttatmnt, and i you a taking oth diabts dugs. You doctwill adjust you dos basd on you blood suga tind th bst dos you. ollow you docto’s dictions caully.

I you ogt you dos at th usual tim, tak it lat that sam day. I you ogt an nti day, howv, dnot « doubl » th dos th nxt day, just sum taking you Actos as usual. I you a unsu what tdo, call you halthca povid.

It is impotant tinstuct patints tadh tditay instuctions and thav blood glucos and glycosylatd hmoglobin tstd gulaly. Duing piods stss such as v, tauma, inction, sugy, mdication quimnts may chang and patints should b mindd tsk mdical advic pomptly. Patints whxpinc an unusually apid incas in wight dma whdvlop shotnss bath oth symptoms hat ailu whil on ACTOS should immdiatly pot ths symptoms ta physician. Tll patints tpomptly stop taking ACTOS and sk immdiat mdical advic i th is unxplaind nausa, vomiting, abdominal pain, atigu, anoxia, dak uin as ths symptoms may b du thpatotoxicity. Tll patints tpomptly pot any sign macoscopichmatuia oth symptoms such as dysuia uinay ugncy that dvlop incas duing tatmnt as ths may b du tbladd canc. Tll patints ttak ACTOS onc daily. ACTOS can b takn with without mals. I a dos is missd on on day, th dos should not b doubld th ollowing day. Whn using combination thapy with insulin oth antidiabtic mdications, th isks hypoglycmia, its symptoms and tatmnt, and conditions that pdispos tits dvlopmnt should b xplaind tpatints and thi amily mmbs. Inom mal patints that tatmnt with ACTOS, lik oth thiazolidindions, may sult in an unintndd pgnancy in som pmnopausal anovulatoy mals du tits ct on ovulation [s Us In Spciic Populations ].

Tabl 9. POactiv: Numb ist and Total vnts ach Componnt within th Cadiovascula Composit ndpoint.

Twclinical tials w conductd with ACTOS in combination with mtomin. Both tials includd patints with typ 2 diabts on any dos mtomin, ith alon in combination with anoth antidiabtic agnt. All oth antidiabtic agnts w withdawn at last th wks pitstating study tatmnt.

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