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Should not be usedsince there is no experience with patients recently transplanted with a kidney.
Cough has been reported with the use of ACE inhibitorsCharacteristicallythe cough is non-productivepersistent and resolves after discontinuation of therapyACE inhibitor-induced cough should be considered as part of the differential diagnosis of cough.
Thiazides should be used with caution in patients with impaired hepatic function or progressive liver diseasesince minor alterations of fluid and electrolyte balance may precipitate hepatic comasee section 4.3RarelyACE inhibitors have been associated with a syndrome that starts with cholestatic jaundice or hepatitis and progresses to fulminant necrosis andsometimesdeathThe mechanism of this syndrome is not understoodPatients receiving lisinopril/hydrochlorothiazide who develop jaundice or marked elevations of hepatic enzymes should discontinue lisinopril/hydrochlorothiazide and receive appropriate medical follow-up.
Because no information is available regarding the use of lisinopril/hydrochlorothiazide during breast-feedinglisinopril/hydrochlorothiazide is not recommended and alternative treatments with better established safety profiles during breast-feeding are preferableespecially while nursing a newborn or preterm infant.
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