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Pioglitazone hydrochloridea component of glimepiride/pioglitazone hydrochloridemay cause or exacerbate congestive heart failuremonitor patients for signs and symptoms of heart failure after initiation or dose increaseShould heart failure developmanage according to current standards of careConsider discontinuation or dose reductionGlimepiride/pioglitazone hydrochloride is not recommended in patients with symptomatic heart failure and is contraindicated in established NYHA Class III or IV heart failure

Kidney function declines as you grow olderThis medication is removed by the kidneysThereforethe elderly may be at greater risk for low blood sugar while using this drug.

This medication is not recommended for use during pregnancyYour doctor may direct you to switch to insulin treatment during your pregnancyUse of pioglitazone/glimepiride close to the expected delivery date may increase the risk of low blood sugar in your newbornConsult your doctor for more detailsand follow all instructions carefully.

Headachedizzinessdiarrheanauseamuscle painsore throator tooth problems may occurIf any of these effects persist or worsentell your doctor or pharmacist promptly.

Appropriate studies have not been performed on the relationship of age to the effects of pioglitazone and glimepiride combination in the pediatric populationSafety and efficacy have not been established.

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