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You should not use Vytorin if you have active liver disease or abnormal liver function tests.

Get emergency medical help if you have signs of an allergic reaction to Vytorinhivesdifficult breathingswelling of your facelipstongueor throat.

In a clinical trial in which 12,064 patients with a history of myocardial infarction were treated with simvastatinmean follow-up 6.7 yearsthe incidence of myopathydefined as unexplained muscle weakness or pain with a serum creatine kinaseCK10 times upper limit of normalULNin patients on 80 mg/day was approximately 0.9compared with 0.02for patients on 20 order nolvadex mg/dayThe incidence of rhabdomyolysisdefined as myopathy with a CK40 times ULNin patients on 80 mg/day was approximately 0.4compared with 0for patients on 20 mg/dayThe incidence of myopathyincluding rhabdomyolysiswas highest during the first year and then notably decreased during the subsequent years of treatmentIn this trialpatients were carefully monitored and some interacting medicinal products were excluded.

Vytorin reduces blood levels ofbadcholesterollow-density lipoproteinor LDLand triglycerideswhile increasing levels ofgoodcholesterolhigh-density lipoproteinor HDL

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