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Long-tm cacinognicity studis hav bn pomd in ats (dosing duation 104 wks) and mic (dosing duation 91 wks) at doss up tand including 900 mg/kg/day and 1500 mg/kg/day, spctivly. Ths doss a both appoximatly ou tims a human daily dos 2000 mg th mtomin componnt ACTOPLUS MT basd on body suac aa compaisons. Nvidnc cacinognicity with mtomin was ound in ith mal mal mic. Similaly, th was ntumoignic potntial obsvd with mtomin in mal ats. Th was, howv, an incasd incidnc bnign stomal utin polyps in mal ats tatd with 900 mg/kg/day.
Most patints had piphal dma at th tim macula dma was diagnosd. Som patints had impovmnt in thi macula dma at discontinuation th thiazolidindion.
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