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In oralgavageembryo-fetal development studies of ezetimibe conducted in rats and rabbits during organogenesisthere was no evidence of embryolethal effects at the doses tested2505001000 mg/kg/dayIn ratsincreased incidences of common fetal skeletal findingsextra pair of thoracic ribsunossified cervical vertebral centrashortened ribswere observed at 1000 mg/kg/day

A 104-week dietary carcinogenicity study with ezetimibe was conducted in rats at doses up to 1500 mg/kg/daymalesand 500 mg/kg/dayfemales

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In oralgavagefertility studies of ezetimibe conducted in ratsthere was no evidence of reproductive toxicity at doses up to 1000 mg/kg/day in male or female rats

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more serious side effects of zetia may demand immediate emergency medical attention and include chest pain pancreatitis fever, sore throat, blistering skin rash muscle weakness, pain nausea, dark urine severe dizziness, trouble breathing.

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