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Renal function can deteriorate if potentially nephrotoxic drugse.gaminoglycosidescephalosporinsfurosemideare given simultaneously and also in patients whose renal function is already impairedRenal function must be monitored carefully in such cases and if deterioration is found discontinuation of the treatment should be consideredsee section 4.4

Renal impairmentSupplemental dose not necessary in hemodialysis or peritoneal dialysis.

There are no adequate and well controlled studies in pregnant womenNo reproductive toxicology studies following parenteral administration are availableReproductive toxicology studies in animals after oral administration showed no teratogenic effectalthough studies in animals have shown reproductive toxicitysee section 5.3If Nimotop solution is to be administered during pregnancythe benefits and the potential risks mustthereforebe carefully weighed according to the severity of the clinical picture.

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