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The study s conclusion was that not only did the the low dose of metoprolol diminish the side effects of sibutramine, but it also did not negatively effect the study subjects metabolism.

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Shortness of breathbeing less able to exercise swelling of the anklesfeet or legs chest tightnesswheezingnoisy breathingdifficulty breathing chest painchanges in heart rate or palpitations swelling of the facelipstongue or throat which may cause difficulty in swallowing or breathingwhich may be signs of a serious allergic reaction yellowing of the skin or eyesjaundicegenerally feeling unwell.

Consider initiating TOPROL-XL therapy at doses lower than those recommended for a given indicationgradually increase dosage to optimize therapywhile monitoring closely for adverse events.

TOPROL-XL is an extended-release tablet intended for once daily administrationFor treatment of hypertension and anginawhen switching from immediate-release metoprolol to TOPROL-XLuse the same total daily dose of TOPROL-XLIndividualize the dosage of TOPROL-XLTitration may be needed in some patients.

Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficulty breathingswelling of your facelipstongueor throat.

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